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Ownership Profile


Shareholder Breakdown
Shareholder Holders Values ($) % O/S Shares
Institution 128 178 78.65 41,622,969
Mutual Fund 131 34 25.79 13,648,776
Institutional Shareholder Rotation
Shareholder Holders Values Change ($) % O/S Shares Change
Buyers 51 4.35 3.24 1,716,984
Sellers 70 -13.88 10.39 -5,499,633
Net -- -9.53 7.15 -3,782,649
Institutional Shareholder Concentration
Shareholder Values ($) % O/S Shares
Top 10 Inst. 156 63.88 33,807,896
Top 20 Inst. 166.05 71.13 37,645,464
Top 50 Inst. 176.02 77.22 40,869,706
Total Inst. 176.02 77.22 40,869,706
Institutional Shareholder Style
Shareholder Holders Values ($) % O/S Shares
Index 19 10 17.37 4,295,000
CoreGrowth 13 3 6.14 1,519,576
AggresGr 1 1 1.03 255,800
Growth 3 0 0.12 29,144
Yield 1 1 0.86 212,334
IncomeValue 2 0 0.47 115,683
GARP 13 19 34.16 8,449,158
BrokerDealer 16 4 6.39 1,580,760
HedgeFund 12 4 6.07 1,502,279
CoreValue 19 15 25.50 6,307,816
DeepValue 5 0 0.69 170,084
Momentum 1 0 0.01 1,594
Top Holders: Institutional Investor
Holder Shares Held % O/S Shares Change Filing Date
Fidelity Management & Research Company 7,938,495 15.00 15,447 12/31/2016
Sanofi SA 5,053,779 9.55 0 03/31/2016
Alnylam Pharmaceuticals, Inc. 4,896,716 9.25 -1,000,000 03/31/2016
Wellington Management Company, LLP 4,683,489 8.85 34,674 12/31/2016
AstraZeneca Plc 3,522,000 6.65 -728,000 03/31/2016
Ionis Pharmaceuticals 2,843,172 5.37 -2,698,133 07/22/2015
BlackRock Institutional Trust Company, N.A. 1,981,606 3.74 -557,000 12/31/2016
South Dakota Investment Council 1,140,928 2.16 240,928 12/31/2016
AXA Investment Managers UK Ltd. 1,066,078 2.01 20,499 12/31/2016
The Vanguard Group, Inc. 681,633 1.29 -655,512 12/31/2016
Wells Fargo Advisors 680,072 1.29 58,753 12/31/2016
State Street Global Advisors (US) 551,941 1.04 -10,387 12/31/2016
Rhenman & Partners Asset Management AB 468,175 0.88 168,175 12/31/2016
Northern Trust Investments, Inc. 376,517 0.71 -24,765 12/31/2016
Millennium Management LLC 376,234 0.71 330,023 12/31/2016
Renaissance Technologies LLC 321,200 0.61 -323,800 12/31/2016
UOB Asset Management Ltd. 295,791 0.56 83,550 06/30/2016
Geode Capital Management, L.L.C. 257,045 0.49 7,277 12/31/2016
Bridgeway Capital Management, Inc. 255,800 0.48 0 12/31/2016
Gibson (Neil W) 254,793 0.48 174,793 03/31/2016
Goldman Sachs & Company, Inc. 228,485 0.43 -167,806 12/31/2016
Ecofi Investissements S.A 212,334 0.40 0 11/30/2016
Papadopoulos (Stelios B) 200,677 0.38 50,677 03/31/2016
TIAA Global Asset Management 195,566 0.37 7,669 12/31/2016
California Public Employees' Retirement System 185,300 0.35 -9,400 12/31/2016
SELECTRA Management Company S.A. 177,000 0.33 0 06/30/2016
RBC Capital Markets Wealth Management 163,397 0.31 -37,603 12/31/2016
Deutsche Asset Management Americas 158,464 0.30 -81,954 12/31/2016
BlackRock Investment Management, LLC 148,265 0.28 0 12/31/2016
Morgan Stanley & Co. LLC 120,465 0.23 104,414 12/31/2016
BNY Mellon Asset Management 115,311 0.22 12,934 12/31/2016
T. Rowe Price Associates, Inc. 114,400 0.22 0 12/31/2016
British Columbia Investment Management Corp. 104,470 0.20 -76,310 03/31/2016
Rastetter (William H) 100,000 0.19 100,000 03/31/2016
A.R.T. Advisors, LLC 90,400 0.17 72,500 12/31/2016
Wedbush Securities, Inc. 87,501 0.17 55,090 12/31/2016
California State Teachers Retirement System 79,843 0.15 -2,300 12/31/2016
Susquehanna Financial Group, LLLP 77,768 0.15 52,801 12/31/2016
Argonaut Capital Management LP 75,000 0.14 75,000 09/30/2015
Columbia Wanger Asset Management, LLC 72,300 0.14 -60,413 09/30/2015
KCG Americas LLC 65,606 0.12 54,526 12/31/2016
D. E. Shaw & Co., L.P. 61,881 0.12 5,007 12/31/2016
Charles Schwab Investment Management, Inc. 61,781 0.12 0 12/31/2016
Credit Suisse Private Banking (Switzerland) 60,000 0.11 0 11/30/2016
Oppenheim Asset Management Services S.à r.l. 50,103 0.09 62 12/31/2016
AllianceBernstein L.P. 47,100 0.09 0 12/31/2016
Tudor Investment Corporation 46,688 0.09 46,688 12/31/2016
ERSTE-SPARINVEST Kapitalanlagegesellschaft mbH 44,650 0.08 0 10/31/2016
Barclays Capital 39,860 0.08 39,426 12/31/2016
Rhumbline Advisers Ltd. Partnership 39,627 0.07 3,165 12/31/2016

Ownership data is provided by Thompson Reuters, a third party service, and Regulus Therapeutics Inc. does not maintain or provide information directly to this service.