OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 32 4.59 23.01 9,010,359
Mutual Fund 12 0.13 0.71 272,205
Insider 9 0.82 4.40 1,723,331

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 12 1.11 5.43 2,126,122
Sellers 21 -1.79 7.02 -2,749,440
Net -0.69 1.59 -623,318

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 5.41 27.41 10,733,690
Top 10 Inst. 5.05 25.62 10,034,136
Top 20 Inst. 5.31 26.89 10,532,232
Top 50 Inst. 5.41 27.41 10,733,690

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth
Aggressive Growth -- --
Core Growth 2 -- -- 931
Growth 1 -- -- 16
Income
Income Value -- --
Yield -- --
Index 5 0.15 0.75 291,907
Other 18 4.40 22.10 8,654,910
Broker Dealer 8 0.13 0.56 219,999
GARP -- --
Hedge Fund 8 2.71 13.46 5,271,345
Specialty -- --
VC Private Equity 2 1.57 8.08 3,163,566
Value 3 0.02 0.09 36,187
Core Value 3 0.02 0.09 36,187
Deep Value -- -- -- --

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
BVF Partners L.P. 3,217,480 8.22 1,767,480 9/30/20
New Enterprise Associates (NEA) 2,052,455 5.24 -- 9/30/20
Sarissa Capital Management, L.P. 1,851,851 4.73 -- 9/30/20
Papadopoulos (Stelios B) 1,193,201 3.05 -846,320 3/31/20
Samsara BioCapital, LLC 1,111,111 2.84 1,111,111 3/31/20
Rastetter (William H) 157,698 0.40 -- 3/31/20
Hagan (Joseph Patrick) 151,743 0.39 -6,094 11/16/20
Citadel Advisors LLC 108,800 0.28 108,800 9/30/20
The Vanguard Group, Inc. 105,449 0.27 72,946 9/30/20
Virtu Americas LLC 84,348 0.22 84,348 6/30/20
Wedbush Securities, Inc. 70,204 0.18 49,629 9/30/20
BlackRock Institutional Trust Company, N.A. 64,811 0.17 -- 9/30/20
Geode Capital Management, L.L.C. 64,347 0.16 -- 9/30/20
Chevallard (Daniel R) 53,857 0.14 21,947 3/31/20
Aker (Christopher Ray) 51,567 0.13 -876 11/16/20
Millennium Management LLC 49,497 0.13 -4,071 9/30/20
Northern Trust Investments, Inc. 42,501 0.11 19,029 9/30/20
Witz (Pascale) 41,013 0.10 -- 3/31/20
Collier (Kathryn J.) 30,931 0.08 10,845 3/31/20
Simplex Trading, LLC 29,368 0.08 14,060 9/30/20
Tower Research Capital LLC 26,707 0.07 -17,479 9/30/20
Baltimore (David) 25,604 0.07 10,274 3/31/20
McGuire Wealth Management 24,000 0.06 4,000 9/30/20
Grimes & Company, Inc. 23,998 0.06 4,500 9/30/20
Rosen (Hugh M.D., Ph.D.) 17,717 0.05 6,519 3/31/20
Two Sigma Investments, LP 16,659 0.04 -11,583 9/30/20
Wells Fargo Advisors 16,616 0.04 -833 9/30/20
California Public Employees' Retirement System 14,799 0.04 -- 9/30/20
Dowling & Yahnke, LLC 12,000 0.03 -- 9/30/20
William Blair & Company, L.L.C. (Research) 11,200 0.03 -- 9/30/20
RBC Capital Markets Wealth Management 6,980 0.02 -125 9/30/20
Valeo Financial Advisors LLC 2,325 0.01 -- 9/30/20
Group One Trading, L.P. 1,200 -- 1,200 9/30/20
Morgan Stanley Smith Barney LLC 730 -- -- 9/30/20
Bourgeon Capital Management, LLC 317 -- -- 9/30/20
Northern Trust Global Investments 201 -- -350 9/30/20
Wells Fargo Bank, N.A. 189 -- 96 9/30/20
RBC Dominion Securities, Inc. 83 -- -- 9/30/20
Steward Partners Investment Advisory, LLC 83 -- -- 9/30/20
Blackstone Alternative Investment Advisors LLC 34 -- 34 6/30/20
Sonora Investment Management, LLC 16 -- -- 9/30/20
UBS Financial Services, Inc. -- -- -902 9/30/20
J.P. Morgan Securities LLC -- -- -65 12/31/19
PanAgora Asset Management Inc. -- -- -776 9/30/19
BNY Mellon Asset Management -- -- -27,298 3/31/19
Victory Capital Management Inc. -- -- -2,913 6/30/20
Manulife Investment Management (North America) Limited -- -- -504 11/30/19
BofA Global Research (US) -- -- -638 6/30/20
Morgan Stanley & Co. LLC -- -- -1,878 6/30/19
Rockefeller Capital Management -- -- -84,642 6/30/20

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