OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 26 6.38 34.31 7,180,253
Mutual Fund 20 0.07 0.46 96,280
Insider 10 1.98 11.98 2,505,914

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 6 1.14 6.80 1,430,766
Sellers 21 -3.51 19.61 -4,125,918
Net -2.37 12.81 -2,695,152

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 8.36 46.29 9,686,167
Top 10 Inst. 7.99 44.38 9,286,138
Top 20 Inst. 8.27 45.85 9,593,712
Top 50 Inst. 8.36 46.29 9,686,167

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth
Aggressive Growth -- --
Core Growth 3 0.10 0.53 110,289
Growth 1 -- -- 16
Income
Income Value -- --
Yield -- --
Index 5 0.16 0.84 175,737
Other 9 5.76 30.92 6,471,510
Broker Dealer 4 0.05 0.26 54,199
GARP -- --
Hedge Fund 4 3.88 20.86 4,364,856
Specialty -- --
VC Private Equity 1 1.83 9.81 2,052,455
Value
Core Value -- --
Deep Value 1 -- 0.03 7,000

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 2,052,455 9.81 -- 12/31/19
Papadopoulos (Stelios B) 2,039,521 9.75 846,320 2/3/20
BVF Partners L.P. 2,035,695 9.73 -- 12/31/19
Sarissa Capital Management, L.P. 1,851,851 8.85 -- 12/31/19
Renaissance Technologies LLC 476,993 2.28 70,300 12/31/19
Heights Capital Management, Inc. 385,973 1.84 385,973 12/31/19
Rastetter (William H) 157,698 0.76 92,891 5/22/19
Hagan (Joseph Patrick) 111,766 0.53 -4,324 2/18/20
Rockefeller Capital Management 109,839 0.52 103,173 12/31/19
Geode Capital Management, L.L.C. 64,347 0.31 -- 12/31/19
BlackRock Institutional Trust Company, N.A. 48,817 0.23 -- 12/31/19
Aker (Christopher Ray) 47,169 0.23 -888 2/18/20
Witz (Pascale) 41,013 0.20 29,630 5/22/19
The Vanguard Group, Inc. 32,503 0.16 -- 12/31/19
Chevallard (Daniel R) 31,910 0.15 -- 7/1/19
Wright (Timothy Michael) 30,223 0.15 -- 5/22/19
Wedbush Securities, Inc. 20,864 0.10 -20,303 12/31/19
Collier (Kathryn J.) 20,086 0.10 -- 5/22/19
McGuire Wealth Management 19,000 0.09 19,000 3/31/20
Wells Fargo Advisors 15,989 0.08 -933 12/31/19
Baltimore (David) 15,330 0.07 -- 5/22/19
Northern Trust Investments, Inc. 15,271 0.07 -- 12/31/19
California Public Employees' Retirement System 14,799 0.07 -- 12/31/19
Rosen (Hugh M.D., Ph.D.) 11,198 0.05 -- 5/22/19
William Blair & Company, L.L.C. (Research) 10,200 0.05 -- 12/31/19
UBS Financial Services, Inc. 8,187 0.04 -8,594 12/31/19
RBC Capital Markets Wealth Management 7,146 0.03 -16 12/31/19
West Oak Capital, LLC 7,000 0.03 6,000 3/31/20
Valeo Financial Advisors LLC 2,325 0.01 -- 12/31/19
Northern Trust Global Investments 350 -- -- 12/31/19
Bourgeon Capital Management, LLC 317 -- -- 12/31/19
Morgan Stanley Smith Barney LLC 100 -- -3 12/31/19
RBC Dominion Securities, Inc. 83 -- -- 12/31/19
Steward Partners Investment Advisory, LLC 83 -- -- 12/31/19
NEXT Financial Group, Inc. 50 -- -- 12/31/19
Sonora Investment Management, LLC 16 -- -- 12/31/19
J.P. Morgan Securities LLC -- -- -65 12/31/19
Goldman Sachs Asset Management (US) -- -- -1,389 9/30/18
PanAgora Asset Management Inc. -- -- -776 9/30/19
BNY Mellon Asset Management -- -- -27,298 3/31/19
Victory Capital Management Inc. -- -- -2,993 12/31/19
Macquarie Investment Management -- -- -1,667 9/30/18
Dimensional Fund Advisors, L.P. -- -- -2,862 1/31/19
Fidelity Management & Research Company -- -- -330,104 11/30/18
Manulife Asset Management Limited -- -- -504 11/30/19
Meeder Asset Management, Inc -- -- -620 9/30/18
BofA Global Research (US) -- -- -455 3/31/19
Morgan Stanley & Co. LLC -- -- -1,878 6/30/19
State Street Global Advisors (US) -- -- -1,995 12/31/18
Candriam Luxembourg S.A. -- -- -41,667 9/30/18

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