OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 81 58.44 67.57 70,489,533
Mutual Fund 37 13.67 17.29 18,034,841
Insider 8 2.44 2.52 2,632,180

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 24 1.37 1.44 1,498,332
Sellers 34 -8.56 9.01 -9,395,898
Net -- -7.19 7.57 -7,897,566

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 58.44 67.57 70,489,533
Top 10 Inst. 51.05 59.28 61,844,522
Top 20 Inst. 55.55 64.50 67,287,571
Top 50 Inst. 58.24 67.38 70,288,519

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 10 1.34 1.77 1,843,558
Core Growth 7 1.31 1.74 1,817,232
Growth 3 0.02 0.03 26,326
Income 2 0.05 0.06 67,448
Income Value 2 0.05 0.06 67,448
Index 9 3.25 4.33 4,519,491
Other 25 32.87 43.91 45,805,064
Broker Dealer 7 0.54 0.72 750,989
GARP 6 12.48 16.68 17,400,498
Hedge Fund 11 11.96 15.97 16,663,667
VC/Private Equi 1 7.89 10.53 10,989,910
Value 8 0.72 0.59 611,027
Core Value 5 0.70 0.56 586,922
Deep Value 3 0.03 0.02 24,105

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 15,593,865 14.95 593 3/31/18
BVF Partners L.P. 13,974,249 13.40 -- 3/31/18
New Enterprise Associates (NEA) 10,989,910 10.53 -- 3/31/18
Sanofi SA 8,706,526 8.35 3,652,747 12/31/17
AstraZeneca Plc 3,522,000 3.38 -- 3/31/17
The Vanguard Group, Inc. 2,784,520 2.67 323,791 3/31/18
Papadopoulos (Stelios B) 1,797,306 1.72 96,629 12/4/17
South Dakota Investment Council 1,776,727 1.70 -- 3/31/18
Boxer Capital, L.L.C. 1,697,802 1.63 -500,000 3/31/18
Ascend Capital, LLC 1,001,617 0.96 -12,389 3/31/18
BlackRock Institutional Trust Company, N.A. 766,787 0.74 -3,952 3/31/18
Point72 Asset Management, L.P. 737,995 0.71 -402,885 3/31/18
Medical Strategy GmbH 712,008 0.68 -- 3/31/18
Hauck & Aufhäuser Asset Management Services S.à r.l. 514,892 0.49 514,892 9/30/17
Candriam Luxembourg S.A. 500,000 0.48 -- 3/31/18
Candriam Belgium S.A. 500,000 0.48 -- 3/31/18
Rhenman & Partners Asset Management AB 492,878 0.47 -- 3/31/18
Geode Capital Management, L.L.C. 483,951 0.46 -- 3/31/18
Wells Fargo Advisors 384,538 0.37 -7,604 3/31/18
Rastetter (William H) 350,000 0.34 250,000 3/31/17
Wright (Timothy Michael) 274,725 0.26 274,725 7/25/17
Hagan (Joseph P) 233,434 0.22 219,780 7/25/17
DZ Bank AG Deutsche Zentral-Genossenschaftsbank 204,733 0.20 204,733 3/31/18
Northern Trust Investments, Inc. 183,271 0.18 -- 3/31/18
California Public Employees' Retirement System 177,600 0.17 -- 3/31/18
SELECTRA Management Company S.A. 177,000 0.17 -- 12/31/16
A.R.T. Advisors, LLC 169,416 0.16 169,416 3/31/18
Wedbush Securities, Inc. 152,559 0.15 -20,736 3/31/18
DRW Securities, LLC 135,000 0.13 35,000 3/31/18
RBC Capital Markets Wealth Management 134,600 0.13 25,000 3/31/18
Renaissance Technologies LLC 128,989 0.12 -8,600 3/31/18
Apo Asset Management GmbH 111,900 0.11 -100 3/31/18
Millennium Management LLC 109,993 0.11 -314,407 3/31/18
Foletta Mark G Iii 81,910 0.08 71,910 12/4/17
PanAgora Asset Management Inc. 79,080 0.08 -- 3/31/18
Virtu Americas LLC 78,587 0.08 78,587 3/31/18
Baltimore (David) 60,674 0.06 60,674 12/4/17
Witz (Pascale) 60,674 0.06 60,674 12/4/17
Collier (Kathryn J.) 60,234 0.06 60,234 4/14/18
Chevallard (Daniel R) 59,415 0.06 54,945 7/25/17
State Street Global Advisors (US) 56,779 0.05 8,910 3/31/18
Rosen (Hugh M.D., Ph.D.) 56,179 0.05 56,179 12/4/17
BNY Mellon Asset Management 34,188 0.03 -- 3/31/18
BNY Mellon Asset Management North America Corporation 33,260 0.03 33,259 3/31/18
USAA Investment Management Company 33,260 0.03 33,260 3/31/18
Invesco PowerShares Capital Management LLC 26,025 0.02 -3,072 3/31/18
Guggenheim Investments 26,025 0.02 158 3/31/18
Hightower Advisors, LLC 22,475 0.02 1,275 3/31/18
Macquarie Investment Management 20,000 0.02 -- 3/31/18
Two Sigma Investments, LP 18,963 0.02 18,963 3/31/18

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