OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 34 12.06 49.11 10,197,566
Mutual Fund 39 0.12 0.52 102,241
Insider 10 2.02 8.18 1,698,424

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 21 9.76 40.01 8,308,580
Sellers 29 -0.58 2.78 -577,884
Net 9.17 37.23 7,730,696

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 23.13 60.78 12,621,534
Top 10 Inst. 22.13 57.03 11,842,158
Top 20 Inst. 22.75 59.72 12,400,813
Top 50 Inst. 23.13 60.78 12,621,534

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth
Aggressive Growth -- --
Core Growth 2 -- -- 453
Growth 2 -- -- 849
Income
Income Value -- --
Yield -- --
Index 5 0.17 0.78 162,787
Other 19 10.30 41.83 8,687,040
Broker Dealer 10 0.22 1.04 216,907
GARP 1 0.16 0.10 20,051
Hedge Fund 6 6.19 25.46 5,286,517
Specialty -- --
VC Private Equity 2 3.73 15.23 3,163,565
Value
Core Value 1 -- -- 504
Deep Value -- --

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 2,052,454 9.88 1,136,703 5/7/19
BVF Partners L.P. 2,035,695 9.80 983,755 5/22/19
Sarissa Capital Management, L.P. 1,851,851 8.92 1,851,851 5/7/19
Altium Capital Management LP 1,327,801 6.39 1,327,801 5/7/19
Papadopoulos (Stelios B) 1,193,201 5.75 360,141 5/22/19
Samsara BioCapital, LLC 1,111,111 5.35 1,111,111 5/22/19
EcoR1 Capital, LLC 1,111,110 5.35 1,111,110 5/22/19
Sanofi SA 725,544 3.49 304,396 12/31/17
Renaissance Technologies LLC 275,693 1.33 115,625 3/31/19
Rastetter (William H) 157,698 0.76 102,735 5/22/19
Hagan (Joseph P) 143,391 0.69 -- 7/1/19
Jane Street Capital, L.L.C. 63,109 0.30 63,109 3/31/19
Aker (Christopher Ray) 54,374 0.26 -2,225 7/1/19
BlackRock Institutional Trust Company, N.A. 48,817 0.24 -- 3/31/19
Virtu Americas LLC 48,652 0.23 48,652 3/31/19
The Vanguard Group, Inc. 43,573 0.21 -181,605 3/31/19
Wedbush Securities, Inc. 43,489 0.21 10,751 3/31/19
Witz (Pascale) 41,013 0.20 22,652 5/22/19
Geode Capital Management, L.L.C. 40,327 0.19 -- 3/31/19
Chevallard (Daniel R) 31,910 0.15 -- 7/1/19
Wright (Timothy Michael) 30,223 0.15 -34,337 5/22/19
Wells Fargo Advisors 22,131 0.11 4,551 3/31/19
Collier (Kathryn J.) 20,086 0.10 -5,470 5/22/19
Medical Strategy GmbH 20,051 0.10 -- 6/30/18
Virtu Financial BD LLC 17,941 0.09 17,941 3/31/19
Susquehanna International Group, LLP 15,384 0.07 15,384 3/31/19
Baltimore (David) 15,330 0.07 -27,787 5/22/19
Northern Trust Investments, Inc. 15,271 0.07 -- 3/31/19
California Public Employees' Retirement System 14,799 0.07 -- 3/31/19
Rosen (Hugh M.D., Ph.D.) 11,198 0.05 -10,388 5/22/19
A.R.T. Advisors, LLC 11,019 0.05 11,019 3/31/19
William Blair & Company, L.L.C. (Research) 10,065 0.05 10,065 3/31/19
RBC Capital Markets Wealth Management 8,035 0.04 -416 3/31/19
UBS Financial Services, Inc. 1,969 0.01 1,034 3/31/19
Morgan Stanley & Co. LLC 1,878 0.01 1,861 3/31/19
Group One Trading, L.P. 1,600 0.01 -- 3/31/19
Tower Research Capital LLC 1,149 0.01 -3,189 3/31/19
Independent Financial Partners 833 -- -416 3/31/19
Bronfman E.L. Rothschild, L.P 729 -- 729 3/31/19
Manulife Asset Management Limited 504 -- -- 6/30/19
Northern Trust Global Investments 350 -- -- 3/31/19
Morgan Stanley Smith Barney LLC 103 -- -- 3/31/19
NEXT Financial Group, Inc. 50 -- -- 6/30/19
Sonora Investment Management, LLC 16 -- -- 6/30/19
Barclays Capital Inc. 7 -- -- 3/31/19
Mellon Investments Corporation -- -- -2,772 6/30/18
J.P. Morgan Securities LLC -- -- -66 12/31/18
Goldman Sachs Asset Management (US) -- -- -1,389 9/30/18
Washington Trust Bank -- -- -13 3/31/18
PanAgora Asset Management Inc. -- -- -22,906 3/31/19

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