OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 65 36.52 54.31 56,934,345
Mutual Fund 24 3.81 10.66 11,175,304
Insider 9 2.45 2.52 2,639,875

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 12 0.14 0.16 165,555
Sellers 42 -5.25 11.49 -12,049,769
Net -- -5.10 11.33 -11,884,214

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 36.52 54.31 56,934,345
Top 10 Inst. 33.40 49.13 51,511,411
Top 20 Inst. 35.64 53.01 55,579,034
Top 50 Inst. 36.47 54.25 56,876,083

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 9 1.18 1.68 1,762,504
Core Growth 7 1.16 1.66 1,740,678
Growth 2 0.02 0.02 21,826
Income 1 0.02 0.03 34,188
Income Value 1 0.02 0.03 34,188
Index 7 2.72 3.94 4,131,819
Other 26 22.46 37.10 38,894,263
Broker Dealer 8 0.40 0.58 608,490
GARP 5 2.98 8.95 9,378,320
Hedge Fund 12 11.83 17.09 17,917,543
VC/Private Equi 1 7.24 10.48 10,989,910
Value 3 0.03 0.04 39,434
Core Value 2 0.02 0.03 32,000
Deep Value 1 -- 0.01 7,434

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
BVF Partners L.P. 13,685,204 13.05 -289,045 6/30/18
New Enterprise Associates (NEA) 10,989,910 10.48 -- 6/30/18
Sanofi SA 8,706,526 8.30 3,652,747 12/31/17
Fidelity Management & Research Company 8,537,762 8.14 -7,110,170 7/31/18
The Vanguard Group, Inc. 2,655,259 2.53 -129,261 6/30/18
Papadopoulos (Stelios B) 1,748,991 1.67 -- 7/31/18
Boxer Capital, L.L.C. 1,697,802 1.62 -- 6/30/18
South Dakota Investment Council 1,683,601 1.61 -93,126 6/30/18
Ascend Capital, LLC 1,068,361 1.02 66,744 6/30/18
Point72 Asset Management, L.P. 737,995 0.70 -- 6/30/18
Rastetter (William H) 659,556 0.63 1 7/31/18
BlackRock Institutional Trust Company, N.A. 585,357 0.56 -181,430 6/30/18
Candriam Luxembourg S.A. 500,000 0.48 -- 6/30/18
Rhenman & Partners Asset Management AB 492,878 0.47 -- 6/30/18
Geode Capital Management, L.L.C. 483,951 0.46 -- 6/30/18
Wells Fargo Advisors 375,972 0.36 -8,566 6/30/18
Wright (Timothy Michael) 294,725 0.28 -- 7/31/18
Hagan (Joseph P) 251,297 0.24 -- 7/31/18
Medical Strategy GmbH 240,616 0.23 -471,392 5/31/18
Northern Trust Investments, Inc. 183,271 0.17 -- 6/30/18
California Public Employees' Retirement System 177,600 0.17 -- 6/30/18
DRW Securities, LLC 135,000 0.13 -- 6/30/18
RBC Capital Markets Wealth Management 133,600 0.13 -1,000 6/30/18
Renaissance Technologies LLC 119,989 0.11 -9,000 6/30/18
PanAgora Asset Management Inc. 84,397 0.08 5,317 6/30/18
Wedbush Securities, Inc. 82,455 0.08 -70,104 6/30/18
Chevallard (Daniel R) 61,520 0.06 -- 7/31/18
Foletta Mark G Iii 45,954 0.04 -35,956 3/31/18
A.R.T. Advisors, LLC 36,471 0.03 -132,945 6/30/18
BNY Mellon Asset Management 34,188 0.03 -- 6/30/18
Baltimore (David) 33,337 0.03 3,001 7/31/18
Witz (Pascale) 30,337 0.03 1 7/31/18
Rosen (Hugh M.D., Ph.D.) 28,089 0.03 1 7/31/18
State Street Global Advisors (US) 26,075 0.02 -30,704 6/30/18
Millennium Management LLC 24,297 0.02 -85,696 6/30/18
Hightower Advisors, LLC 22,475 0.02 -- 6/30/18
Invesco Capital Management LLC 20,306 0.02 -5,719 6/30/18
Macquarie Investment Management 20,000 0.02 -- 6/30/18
Tower Research Capital LLC 19,423 0.02 12,060 6/30/18
Collier (Kathryn J.) 18,984 0.02 -48,945 7/31/18
Goldman Sachs Asset Management (US) 16,670 0.02 16,670 6/30/18
Mariner Wealth Advisors, LLC 15,545 0.01 -- 6/30/18
UBS Financial Services, Inc. 15,004 0.01 15,004 6/30/18
Independent Financial Partners 15,000 0.01 -- 6/30/18
Brown Advisory Securities, LLC 15,000 0.01 15,000 6/30/18
First Financial Equity Corporation 13,910 0.01 13,910 3/31/17
Bourgeon Capital Management, LLC 13,304 0.01 -- 6/30/18
Brookstone Capital Management, LLC 13,200 0.01 -- 6/30/18
Movestic Livsförsäkring AB 12,919 0.01 12,919 12/31/16
Dowling & Yahnke, LLC 12,000 0.01 -- 6/30/18

Copyright Thomson Reuters Corporation