OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 76 50.48 63.31 66,048,423
Mutual Fund 29 12.82 16.27 16,977,625
Insider 9 2.45 2.53 2,639,875

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 21 0.72 0.94 980,279
Sellers 26 -3.03 4.10 -4,278,981
Net -- -2.32 3.16 -3,298,702

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 50.48 63.31 66,048,423
Top 10 Inst. 45.17 56.60 59,040,994
Top 20 Inst. 48.42 60.95 63,586,549
Top 50 Inst. 50.35 63.17 65,897,065

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 9 1.34 1.76 1,839,058
Core Growth 7 1.31 1.74 1,817,232
Growth 2 0.02 0.02 21,826
Income 1 0.02 0.03 34,188
Income Value 1 0.02 0.03 34,188
Index 8 3.24 4.33 4,512,193
Other 25 32.52 43.46 45,333,672
Broker Dealer 7 0.54 0.72 750,989
GARP 6 12.14 16.23 16,929,106
Hedge Fund 11 11.96 15.97 16,663,667
VC/Private Equi 1 7.89 10.53 10,989,910
Value 7 0.07 0.10 102,827
Core Value 4 0.05 0.07 72,030
Deep Value 3 0.02 0.03 30,797

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
Fidelity Management & Research Company 15,593,865 14.95 593 3/31/18
BVF Partners L.P. 13,974,249 13.40 -- 3/31/18
New Enterprise Associates (NEA) 10,989,910 10.53 -- 3/31/18
Sanofi SA 8,706,526 8.35 3,652,747 12/31/17
The Vanguard Group, Inc. 2,784,520 2.67 323,791 3/31/18
South Dakota Investment Council 1,776,727 1.70 -- 3/31/18
Papadopoulos (Stelios B) 1,748,991 1.68 -48,315 3/31/18
Boxer Capital, L.L.C. 1,697,802 1.63 -500,000 3/31/18
Ascend Capital, LLC 1,001,617 0.96 -12,389 3/31/18
BlackRock Institutional Trust Company, N.A. 766,787 0.74 -3,952 3/31/18
Point72 Asset Management, L.P. 737,995 0.71 -402,885 3/31/18
Rastetter (William H) 659,555 0.63 309,555 3/31/18
Candriam Luxembourg S.A. 500,000 0.48 -- 3/31/18
Candriam Belgium S.A. 500,000 0.48 -- 5/31/18
Rhenman & Partners Asset Management AB 492,878 0.47 -- 3/31/18
Geode Capital Management, L.L.C. 483,951 0.46 -- 3/31/18
Wells Fargo Advisors 384,538 0.37 -7,604 3/31/18
Wright (Timothy Michael) 294,725 0.28 20,000 3/31/18
Hagan (Joseph P) 251,297 0.24 17,863 3/31/18
Medical Strategy GmbH 240,616 0.23 -471,392 4/30/18
DZ Bank AG Deutsche Zentral-Genossenschaftsbank 204,733 0.20 204,733 3/31/18
Northern Trust Investments, Inc. 183,271 0.18 -- 3/31/18
California Public Employees' Retirement System 177,600 0.17 -- 3/31/18
SELECTRA Management Company S.A. 177,000 0.17 -- 12/31/16
A.R.T. Advisors, LLC 169,416 0.16 169,416 3/31/18
Wedbush Securities, Inc. 152,559 0.15 -20,736 3/31/18
DRW Securities, LLC 135,000 0.13 35,000 3/31/18
RBC Capital Markets Wealth Management 134,600 0.13 25,000 3/31/18
Renaissance Technologies LLC 128,989 0.12 -8,600 3/31/18
Millennium Management LLC 109,993 0.11 -314,407 3/31/18
PanAgora Asset Management Inc. 79,080 0.08 -- 3/31/18
Virtu Americas LLC 78,587 0.08 78,587 3/31/18
Collier (Kathryn J.) 67,929 0.07 67,929 6/5/18
Chevallard (Daniel R) 61,520 0.06 2,105 3/31/18
State Street Global Advisors (US) 56,779 0.05 8,910 3/31/18
Foletta Mark G Iii 45,954 0.04 -35,956 3/31/18
BNY Mellon Asset Management 34,188 0.03 -- 3/31/18
USAA Asset Management Company 33,260 0.03 33,260 3/31/18
BNY Mellon Asset Management North America Corporation 33,260 0.03 33,259 3/31/18
Baltimore (David) 30,336 0.03 -30,338 3/31/18
Witz (Pascale) 30,336 0.03 -30,338 3/31/18
Rosen (Hugh M.D., Ph.D.) 28,088 0.03 -28,091 3/31/18
Guggenheim Investments 26,025 0.02 158 3/31/18
Invesco PowerShares Capital Management LLC 26,025 0.02 -- 5/31/18
Hightower Advisors, LLC 22,475 0.02 1,275 3/31/18
Macquarie Investment Management 20,000 0.02 -- 3/31/18
Two Sigma Investments, LP 18,963 0.02 18,963 3/31/18
Mariner Wealth Advisors, LLC 15,545 0.01 -21,855 3/31/18
Independent Financial Partners 15,000 0.01 -- 3/31/18
BlackRock Investment Management, LLC 14,005 0.01 -- 3/31/18

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