OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 34 38.76 75.18 29,443,407
Mutual Fund 10 11.70 22.09 8,652,508
Insider 9 3.09 6.41 2,511,887

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 22 29.18 55.18 21,611,513
Sellers 19 -0.53 1.38 -539,621
Net 28.64 53.81 21,071,892

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 41.85 81.60 31,955,294
Top 10 Inst. 39.54 76.65 30,020,278
Top 20 Inst. 41.43 80.59 31,562,847
Top 50 Inst. 41.85 81.60 31,955,294

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth
Aggressive Growth -- --
Core Growth 2 0.68 1.29 505,619
Growth 1 -- -- 16
Income
Income Value -- --
Yield -- --
Index 4 0.73 1.38 540,225
Other 18 26.50 51.99 20,359,492
Broker Dealer 7 0.13 0.24 93,403
GARP -- --
Hedge Fund 9 17.15 32.44 12,703,922
Specialty -- --
VC Private Equity 2 9.22 19.31 7,562,167
Value
Core Value 4 8.55 16.18 6,336,829
Deep Value -- --

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 6,451,056 16.47 4,398,601 12/31/20
Wellington Management Company, LLP 6,270,099 16.01 6,270,099 12/31/20
EcoR1 Capital, LLC 3,650,080 9.32 3,650,080 12/31/20
BVF Partners L.P. 3,376,207 8.62 158,727 12/31/20
Point72 Asset Management, L.P. 3,215,436 8.21 3,215,436 12/31/20
Papadopoulos (Stelios B) 1,986,729 5.07 793,528 12/4/20
Sarissa Capital Management, L.P. 1,851,851 4.73 -- 12/31/20
Heights Capital Management, Inc. 1,607,720 4.11 1,607,720 12/31/20
Samsara BioCapital, LLC 1,111,111 2.84 1,111,111 3/31/20
Victory Capital Management Inc. 499,989 1.28 499,989 12/31/20
Renaissance Technologies LLC 449,200 1.15 449,200 12/31/20
The Vanguard Group, Inc. 386,659 0.99 281,210 12/31/20
Rastetter (William H) 157,698 0.40 -- 3/31/20
Hagan (Joseph Patrick) 147,599 0.38 -4,144 2/16/21
Tower Research Capital LLC 120,986 0.31 94,279 12/31/20
Geode Capital Management, L.L.C. 64,347 0.16 -- 12/31/20
Goldman Sachs & Company, Inc. 56,336 0.14 56,336 12/31/20
Grimes & Company, Inc. 54,511 0.14 30,513 12/31/20
Chevallard (Daniel R) 53,857 0.14 21,947 3/31/20
GYL Financial Synergies, LLC 51,376 0.13 51,376 12/31/20
Aker (Christopher Ray) 50,739 0.13 -828 2/16/21
BlackRock Institutional Trust Company, N.A. 49,788 0.13 -15,023 12/31/20
Witz (Pascale) 41,013 0.10 -- 3/31/20
Northern Trust Investments, Inc. 39,431 0.10 -3,070 12/31/20
Collier (Kathryn J.) 30,931 0.08 10,845 3/31/20
Two Sigma Investments, LP 29,716 0.08 13,057 12/31/20
Baltimore (David) 25,604 0.07 10,274 3/31/20
McGuire Wealth Management 24,000 0.06 -- 12/31/20
Rosen (Hugh M.D., Ph.D.) 17,717 0.05 6,519 3/31/20
Altus Wealth Management, LLC 13,805 0.04 13,805 12/31/20
Dowling & Yahnke, LLC 12,000 0.03 -- 12/31/20
William Blair & Company, L.L.C. (Research) 11,200 0.03 -- 12/31/20
Squarepoint Capital LLP 10,129 0.03 10,129 12/31/20
Group One Trading, L.P. 8,900 0.02 7,700 12/31/20
Wells Fargo Advisors 7,106 0.02 -9,510 12/31/20
RBC Capital Markets Wealth Management 6,980 0.02 -- 12/31/20
Morgan Stanley Smith Barney LLC 5,630 0.01 4,900 12/31/20
Valeo Financial Advisors LLC 4,325 0.01 2,000 12/31/20
UBS Financial Services, Inc. 2,798 0.01 2,798 12/31/20
Bourgeon Capital Management, LLC 317 -- -- 12/31/20
Wells Fargo Bank, N.A. 219 -- 30 12/31/20
RBC Dominion Securities, Inc. 83 -- -- 12/31/20
Sonora Investment Management, LLC 16 -- -- 12/31/20
J.P. Morgan Securities LLC -- -- -65 12/31/19
PanAgora Asset Management Inc. -- -- -776 9/30/19
California Public Employees' Retirement System -- -- -14,799 12/31/20
Manulife Investment Management (North America) Limited -- -- -504 11/30/19
BofA Global Research (US) -- -- -638 6/30/20
Wedbush Securities, Inc. -- -- -70,204 12/31/20
Morgan Stanley & Co. LLC -- -- -1,878 6/30/19

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