OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 48 7.17 52.98 4,636,280
Mutual Fund 14 0.36 3.90 341,250
Insider 9 2.16 19.17 1,677,642

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 11 0.19 0.89 78,048
Sellers 29 -1.17 7.61 -665,900
Net -- -0.99 6.72 -587,852

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 7.17 52.98 4,636,280
Top 10 Inst. 6.39 48.17 4,215,150
Top 20 Inst. 6.93 51.55 4,510,860
Top 50 Inst. 7.17 52.98 4,636,280

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 5 0.07 0.36 31,728
Core Growth 3 0.07 0.36 31,142
Growth 2 -- 0.01 586
Income 1 0.01 0.03 2,849
Income Value 1 0.01 0.03 2,849
Index 7 0.81 3.89 340,203
Other 18 4.48 28.10 2,459,074
Broker Dealer 7 0.12 0.57 49,571
GARP 3 0.04 0.36 31,936
Hedge Fund 7 3.47 16.71 1,461,816
VC/Private Equi 1 0.85 10.47 915,751
Value 1 -- 0.01 1,000
Core Value 1 -- 0.01 1,000

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
BVF Partners L.P. 1,140,434 13.03 -- 9/30/18
New Enterprise Associates (NEA) 915,751 10.47 -- 12/31/18
Papadopoulos (Stelios B) 833,060 9.52 687,311 12/28/18
Sanofi SA 725,544 8.29 304,396 12/31/17
The Vanguard Group, Inc. 217,892 2.49 -3,380 9/30/18
Boxer Capital, L.L.C. 141,484 1.62 -- 9/30/18
Ascend Capital, LLC 87,578 1.00 -1,452 9/30/18
Rastetter (William H) 54,963 0.63 -- 7/31/18
Renaissance Technologies LLC 49,625 0.57 39,626 9/30/18
BlackRock Institutional Trust Company, N.A. 48,819 0.56 39 9/30/18
Baltimore (David) 43,117 0.49 40,339 11/12/18
Rhenman & Partners Asset Management AB 41,073 0.47 -- 9/30/18
Geode Capital Management, L.L.C. 40,329 0.46 -- 9/30/18
South Dakota Investment Council 30,645 0.35 -109,655 9/30/18
Collier (Kathryn J.) 25,556 0.29 23,974 11/16/18
Wright (Timothy Michael) 24,560 0.28 -- 7/31/18
Susquehanna International Group, LLP 24,387 0.28 24,387 9/30/18
Wells Fargo Advisors 23,516 0.27 -7,815 9/30/18
Rosen (Hugh M.D., Ph.D.) 21,586 0.25 19,245 11/12/18
Hagan (Joseph P) 20,941 0.24 -- 7/31/18
Medical Strategy GmbH 20,051 0.23 -39,283 6/30/18
Witz (Pascale) 18,361 0.21 15,833 11/12/18
Northern Trust Investments, Inc. 14,864 0.17 -409 9/30/18
California Public Employees' Retirement System 14,800 0.17 -- 9/30/18
Wedbush Securities, Inc. 13,015 0.15 6,144 9/30/18
RBC Capital Markets Wealth Management 11,050 0.13 -83 9/30/18
PanAgora Asset Management Inc. 10,590 0.12 3,557 9/30/18
Chevallard (Daniel R) 5,127 0.06 -- 7/31/18
BNY Mellon Asset Management 2,849 0.03 -- 9/30/18
We Are One Seven, LLC 2,000 0.02 2,000 9/30/18
State Street Global Advisors (US) 1,995 0.02 -178 9/30/18
Invesco Capital Management LLC 1,504 0.02 -188 9/30/18
Two Sigma Investments, LP 1,455 0.02 1,455 9/30/18
UBS Financial Services, Inc. 1,340 0.02 90 9/30/18
Mariner Wealth Advisors, LLC 1,295 0.01 -- 9/30/18
Brown Advisory Securities, LLC 1,250 0.01 -- 9/30/18
Dowling & Yahnke, LLC 1,000 0.01 -- 9/30/18
FIDE Capital 833 0.01 -- 9/30/18
Barclays Capital Inc. 666 0.01 659 9/30/18
Emerald Advisers, Inc. 569 0.01 -- 4/30/17
Northern Trust Global Investments 352 -- -- 9/30/18
Ladenburg Thalmann Asset Management Inc. (LTAM) 167 -- -575 9/30/18
Morgan Stanley Wealth Management 145 -- 41 9/30/18
J.P. Morgan Securities LLC 66 -- -- 9/30/18
NEXT Financial Group, Inc. 50 -- 50 9/30/18
Sonora Investment Management, LLC 17 -- -- 9/30/18
Morgan Stanley & Co. LLC 8 -- -40 9/30/18
RBC Dominion Securities, Inc. 1 -- -375 9/30/18

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