OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 30 4.48 35.22 9,725,082
Mutual Fund 14 0.07 0.36 99,193
Insider 9 0.86 6.29 1,735,418

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 15 1.48 11.60 3,202,605
Sellers 16 -2.52 12.77 -3,524,358
Net -1.05 1.17 -321,753

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 5.35 41.51 11,460,500
Top 10 Inst. 5.03 39.14 10,804,767
Top 20 Inst. 5.28 40.97 11,310,437
Top 50 Inst. 5.35 41.51 11,460,500

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth
Aggressive Growth -- --
Core Growth 4 0.04 0.32 88,005
Growth 1 -- -- 16
Income
Income Value -- --
Yield -- --
Index 5 0.08 0.64 175,737
Other 13 4.19 32.92 9,088,948
Broker Dealer 6 0.04 0.28 76,997
GARP -- --
Hedge Fund 5 2.70 21.18 5,848,385
Specialty -- --
VC Private Equity 2 1.46 11.46 3,163,566
Value 1 -- -- 92
Core Value 1 -- -- 92
Deep Value -- -- -- --

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 2,052,455 7.43 -- 3/31/20
EcoR1 Capital, LLC 1,886,812 6.83 1,886,812 3/31/20
Sarissa Capital Management, L.P. 1,851,851 6.71 -- 3/31/20
BVF Partners L.P. 1,592,923 5.77 -442,772 3/31/20
Papadopoulos (Stelios B) 1,193,201 4.32 -846,320 3/31/20
Samsara BioCapital, LLC 1,111,111 4.02 1,111,111 3/31/20
Renaissance Technologies LLC 516,482 1.87 39,489 3/31/20
Heights Capital Management, Inc. 280,152 1.01 -105,821 3/31/20
Hagan (Joseph Patrick) 162,082 0.59 -4,426 5/15/20
Rastetter (William H) 157,698 0.57 -- 3/31/20
Rockefeller Capital Management 84,642 0.31 -25,197 3/31/20
Susquehanna International Group, LLP 70,641 0.26 70,641 3/31/20
Geode Capital Management, L.L.C. 64,347 0.23 -- 3/31/20
Chevallard (Daniel R) 53,857 0.20 21,947 3/31/20
Aker (Christopher Ray) 53,315 0.19 -909 5/15/20
BlackRock Institutional Trust Company, N.A. 48,817 0.18 -- 3/31/20
Witz (Pascale) 41,013 0.15 -- 3/31/20
The Vanguard Group, Inc. 32,503 0.12 -- 3/31/20
Collier (Kathryn J.) 30,931 0.11 10,845 3/31/20
Baltimore (David) 25,604 0.09 10,274 3/31/20
Wells Fargo Advisors 22,005 0.08 6,016 3/31/20
Wedbush Securities, Inc. 20,741 0.08 -123 3/31/20
McGuire Wealth Management 19,000 0.07 19,000 3/31/20
Rosen (Hugh M.D., Ph.D.) 17,717 0.06 6,519 3/31/20
Simplex Trading, LLC 15,308 0.06 15,308 3/31/20
Northern Trust Investments, Inc. 15,271 0.06 -- 3/31/20
California Public Employees' Retirement System 14,799 0.05 -- 3/31/20
William Blair & Company, L.L.C. (Research) 11,200 0.04 1,000 3/31/20
RBC Capital Markets Wealth Management 7,105 0.03 -41 3/31/20
Victory Capital Management Inc. 2,913 0.01 2,913 3/31/20
Valeo Financial Advisors LLC 2,325 0.01 -- 3/31/20
BofA Global Research (US) 638 -- 638 3/31/20
Northern Trust Global Investments 350 -- -- 3/31/20
Bourgeon Capital Management, LLC 317 -- -- 3/31/20
Morgan Stanley Smith Barney LLC 100 -- -- 3/31/20
Wells Fargo Bank, N.A. 92 -- 92 3/31/20
RBC Dominion Securities, Inc. 83 -- -- 3/31/20
Steward Partners Investment Advisory, LLC 83 -- -- 3/31/20
Sonora Investment Management, LLC 16 -- -- 3/31/20
UBS Financial Services, Inc. -- -- -8,187 3/31/20
J.P. Morgan Securities LLC -- -- -65 12/31/19
PanAgora Asset Management Inc. -- -- -776 9/30/19
BNY Mellon Asset Management -- -- -27,298 3/31/19
Dimensional Fund Advisors, L.P. -- -- -2,862 1/31/19
Fidelity Management & Research Company -- -- -330,104 11/30/18
Manulife Asset Management Limited -- -- -504 11/30/19
Morgan Stanley & Co. LLC -- -- -1,878 6/30/19
State Street Global Advisors (US) -- -- -1,995 12/31/18
Citadel Advisors LLC -- -- -10,671 3/31/19
Dowling & Yahnke, LLC -- -- -1,000 12/31/18

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