OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 29 7.09 43.10 9,002,532
Mutual Fund 36 0.07 0.50 102,241
Insider 10 1.86 8.04 1,675,390

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 13 2.22 9.17 1,918,500
Sellers 19 -1.17 7.48 -1,564,755
Net 1.05 1.69 353,745

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 9.71 54.71 11,420,246
Top 10 Inst. 9.31 52.33 10,924,460
Top 20 Inst. 9.61 54.14 11,301,744
Top 50 Inst. 9.71 54.71 11,420,246

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth
Aggressive Growth -- --
Core Growth 4 0.01 0.05 10,112
Growth 1 -- -- 16
Income
Income Value -- --
Yield -- --
Index 5 0.13 0.84 175,737
Other 12 5.39 35.82 7,484,821
Broker Dealer 5 0.05 0.36 75,516
GARP -- -- -- --
Hedge Fund 6 3.86 25.60 5,356,850
Specialty -- --
VC Private Equity 1 1.48 9.86 2,052,455
Value 2 -- 0.01 1,504
Core Value 1 -- -- 504
Deep Value 1 -- -- 1,000

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 2,052,455 9.86 -- 9/30/19
BVF Partners L.P. 2,035,695 9.73 -- 9/30/19
Sarissa Capital Management, L.P. 1,851,851 8.85 -- 9/30/19
Altium Capital Management LP 1,327,801 6.38 1,327,801 5/7/19
Papadopoulos (Stelios B) 1,193,201 5.73 370,370 5/22/19
EcoR1 Capital, LLC 1,049,088 5.01 -62,022 9/30/19
Sanofi SA 725,543 3.48 -1 3/31/19
Renaissance Technologies LLC 406,693 1.94 59,800 9/30/19
Rastetter (William H) 157,698 0.76 92,891 5/22/19
Hagan (Joseph Patrick) 124,435 0.59 -5,838 11/14/19
Geode Capital Management, L.L.C. 64,347 0.31 -- 9/30/19
Aker (Christopher Ray) 50,296 0.24 -833 11/14/19
BlackRock Institutional Trust Company, N.A. 48,817 0.23 -- 9/30/19
Wedbush Securities, Inc. 41,167 0.20 7,791 9/30/19
Witz (Pascale) 41,013 0.20 29,630 5/22/19
The Vanguard Group, Inc. 32,503 0.16 -- 9/30/19
Chevallard (Daniel R) 31,910 0.15 -- 7/1/19
Wright (Timothy Michael) 30,223 0.15 -- 5/22/19
Collier (Kathryn J.) 20,086 0.10 -- 5/22/19
Wells Fargo Advisors 16,922 0.08 -255 9/30/19
UBS Financial Services, Inc. 16,781 0.08 16,781 9/30/19
Baltimore (David) 15,330 0.07 -- 5/22/19
Northern Trust Investments, Inc. 15,271 0.07 -- 9/30/19
California Public Employees' Retirement System 14,799 0.07 -- 9/30/19
Verition Fund Management LLC 13,206 0.06 -- 9/30/19
Rosen (Hugh M.D., Ph.D.) 11,198 0.05 -- 5/22/19
William Blair & Company, L.L.C. (Research) 10,200 0.05 135 9/30/19
RBC Capital Markets Wealth Management 7,162 0.03 -666 9/30/19
Rockefeller Financial 6,666 0.03 6,666 9/30/19
Victory Capital Management Inc. 2,993 0.01 2,993 9/30/19
Valeo Financial Advisors LLC 2,325 0.01 2,325 9/30/19
West Oak Capital, LLC 1,000 -- 1,000 9/30/19
Manulife Asset Management Limited 504 -- -- 9/30/19
Northern Trust Global Investments 350 -- -- 9/30/19
Bourgeon Capital Management, LLC 317 -- 317 9/30/19
Morgan Stanley Smith Barney LLC 103 -- -- 9/30/19
RBC Dominion Securities, Inc. 83 -- -- 9/30/19
Steward Partners Investment Advisory, LLC 83 -- -- 9/30/19
J.P. Morgan Securities LLC 65 -- -- 9/30/19
NEXT Financial Group, Inc. 50 -- -- 9/30/19
Sonora Investment Management, LLC 16 -- -- 9/30/19
Mellon Investments Corporation -- -- -2,772 6/30/18
Goldman Sachs Asset Management (US) -- -- -1,389 9/30/18
Washington Trust Bank -- -- -13 3/31/18
PanAgora Asset Management Inc. -- -- -776 9/30/19
BNY Mellon Asset Management -- -- -27,298 3/31/19
Deutsche Asset Management Americas -- -- -8 6/30/18
Macquarie Investment Management -- -- -1,667 9/30/18
Dimensional Fund Advisors, L.P. -- -- -2,862 1/31/19
Fidelity Management & Research Company -- -- -330,104 11/30/18

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