OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 40 53.05 58.38 35,226,999
Mutual Fund 13 18.13 16.04 11,623,071
Insider 8 5.73 4.96 3,708,911

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 25 13.86 13.47 10,092,480
Sellers 18 -11.65 10.02 -7,506,282
Net 2.20 3.45 2,586,198

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 58.78 63.34 38,935,910
Top 10 Inst. 54.52 58.77 36,087,553
Top 20 Inst. 58.09 62.67 38,485,264
Top 50 Inst. 58.78 63.34 38,935,910

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth
Aggressive Growth -- --
Core Growth 4 3.52 3.02 2,259,579
Growth 1 -- -- 16
Income
Income Value -- --
Yield -- --
Index 5 1.35 1.69 915,284
Other 16 35.04 39.89 23,413,732
Broker Dealer 6 0.14 0.20 95,073
GARP -- --
Hedge Fund 9 24.84 31.08 16,867,602
Specialty -- --
VC Private Equity 1 10.06 8.61 6,451,057
Value 7 10.66 9.40 6,834,167
Core Value 4 9.90 8.75 6,343,489
Deep Value 3 0.77 0.66 490,678

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 6,451,057 8.61 -- 3/31/21
Wellington Management Company, LLP 6,270,099 8.65 -- 3/31/21
BVF Partners L.P. 5,988,932 7.99 -- 3/31/21
EcoR1 Capital, LLC 3,650,080 9.32 3,650,080 12/31/20
Point72 Asset Management, L.P. 3,215,436 8.21 3,215,436 12/31/20
Papadopoulos (Stelios B) 2,839,707 3.79 -- 3/31/21
Victory Capital Management Inc. 2,227,199 2.97 -6,292,043 3/31/21
Asymmetry Capital Management, L.P 1,985,472 2.65 -426,104 3/31/21
Sarissa Capital Management, L.P. 1,851,851 2.47 -- 3/31/21
Heights Capital Management, Inc. 1,607,720 4.11 1,607,720 12/31/20
Acadian Asset Management LLC 465,678 0.62 465,678 3/31/21
Rastetter (William H) 390,581 0.52 -- 3/31/21
The Vanguard Group, Inc. 386,659 0.99 281,210 12/31/20
Geode Capital Management, L.L.C. 381,892 0.51 317,545 3/31/21
Hagan (Joseph Patrick) 316,934 0.44 75,850 4/14/21
Tower Research Capital LLC 120,986 0.31 94,279 12/31/20
Northern Trust Investments, Inc. 117,654 0.16 78,223 3/31/21
Focused Wealth Management, Inc. 100,000 0.13 100,000 3/31/21
Grimes & Company, Inc. 60,991 0.08 6,480 3/31/21
Goldman Sachs & Company, Inc. 56,336 0.14 56,336 12/31/20
GYL Financial Synergies, LLC 51,376 0.07 -- 3/31/21
Witz (Pascale) 47,335 0.06 -6 3/31/21
Aker (Christopher Ray) 43,614 0.06 -- 3/31/21
Two Sigma Investments, LP 29,716 0.08 13,057 12/31/20
Collier (Kathryn J.) 27,419 0.04 -- 3/31/21
Charles Schwab Investment Management, Inc. 26,759 0.04 26,759 3/31/21
Baltimore (David) 25,604 0.03 -- 3/31/21
McGuire Wealth Management 24,000 0.03 -- 3/31/21
Commonwealth Financial Network 20,000 0.03 20,000 3/31/21
Rosen (Hugh M.D., Ph.D.) 17,717 0.02 -- 3/31/21
Axiom Investment Management, LLC 15,000 0.02 15,000 3/31/21
Group One Trading, L.P. 13,868 0.02 4,968 3/31/21
Axiom Asset Management 13,000 0.02 13,000 3/31/21
Dowling & Yahnke, LLC 12,000 0.02 -- 3/31/21
Creative Planning, Inc. 12,000 0.02 12,000 3/31/21
William Blair & Company, L.L.C. (Research) 10,700 0.01 -500 3/31/21
Squarepoint Capital LLP 10,129 0.03 10,129 12/31/20
Private Advisor Group LLC 10,000 0.01 10,000 3/31/21
Wells Fargo Advisors 7,106 0.01 -- 3/31/21
RBC Capital Markets Wealth Management 6,980 0.02 -- 12/31/20
Community Bank, N.A. 6,900 0.01 6,900 3/31/21
Endurance Wealth Management, Inc. 6,750 0.01 6,750 3/31/21
Morgan Stanley Smith Barney LLC 5,630 0.01 4,900 12/31/20
Valeo Financial Advisors LLC 4,225 0.01 -100 3/31/21
BlackRock Institutional Trust Company, N.A. 2,320 -- -47,468 3/31/21
Wells Fargo Bank, N.A. 399 -- 180 3/31/21
RBC Dominion Securities, Inc. 83 -- -- 12/31/20
Sonora Investment Management, LLC 16 -- -- 3/31/21
Altus Wealth Management, LLC -- -- -13,805 3/31/21
Seasons of Advice Wealth Management -- -- -989 3/31/21

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