OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 36 4.83 23.95 7,448,898
Mutual Fund 14 0.07 0.36 100,225
Insider 9 0.81 6.09 1,730,301

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 22 0.78 4.21 1,514,116
Sellers 15 -2.19 9.71 -3,488,091
Net -1.41 5.50 -1,973,975

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 5.64 30.04 9,179,199
Top 10 Inst. 5.17 27.54 8,418,822
Top 20 Inst. 5.46 29.08 8,891,485
Top 50 Inst. 5.64 30.04 9,179,199

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth
Aggressive Growth -- --
Core Growth 2 -- -- 1,281
Growth 1 -- -- 16
Income
Income Value -- --
Yield -- --
Index 5 0.14 0.62 199,932
Other 21 4.65 23.07 7,175,993
Broker Dealer 11 0.19 0.93 277,205
GARP -- --
Hedge Fund 8 2.55 10.68 3,735,222
Specialty -- --
VC Private Equity 2 1.91 11.46 3,163,566
Value 4 0.03 0.18 49,268
Core Value 3 0.02 0.11 31,591
Deep Value 1 0.01 0.06 17,677

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 2,052,455 7.43 -- 6/30/20
Sarissa Capital Management, L.P. 1,851,851 5.16 -- 6/30/20
BVF Partners L.P. 1,450,000 4.04 -142,923 6/30/20
Papadopoulos (Stelios B) 1,193,201 4.32 -846,320 3/31/20
Samsara BioCapital, LLC 1,111,111 4.02 1,111,111 3/31/20
Renaissance Technologies LLC 295,258 1.07 -221,224 6/30/20
Hagan (Joseph Patrick) 157,837 0.44 -4,245 8/14/20
Rastetter (William H) 157,698 0.57 -- 3/31/20
Virtu Americas LLC 84,348 0.31 84,348 6/30/20
Susquehanna International Group, LLP 65,063 0.18 -5,578 6/30/20
BlackRock Institutional Trust Company, N.A. 64,811 0.18 15,994 6/30/20
Geode Capital Management, L.L.C. 64,347 0.23 -- 6/30/20
Chevallard (Daniel R) 53,857 0.20 21,947 3/31/20
Millennium Management LLC 53,568 0.15 53,568 6/30/20
Aker (Christopher Ray) 52,443 0.15 -872 8/14/20
Tower Research Capital LLC 44,186 0.16 44,186 6/30/20
Witz (Pascale) 41,013 0.15 -- 3/31/20
SG Americas Securities, L.L.C. 35,004 0.13 35,004 6/30/20
The Vanguard Group, Inc. 32,503 0.09 -- 6/30/20
Collier (Kathryn J.) 30,931 0.11 10,845 3/31/20
Two Sigma Investments, LP 28,242 0.08 28,242 6/30/20
Baltimore (David) 25,604 0.09 10,274 3/31/20
Northern Trust Investments, Inc. 23,472 0.07 8,201 6/30/20
Wedbush Securities, Inc. 20,575 0.07 -166 6/30/20
Jane Street Capital, L.L.C. 20,168 0.06 20,168 6/30/20
McGuire Wealth Management 20,000 0.07 1,000 6/30/20
Grimes & Company, Inc. 19,498 0.07 19,498 6/30/20
Rosen (Hugh M.D., Ph.D.) 17,717 0.06 6,519 3/31/20
Acadian Asset Management LLC 17,677 0.06 17,677 6/30/20
Wells Fargo Advisors 17,449 0.06 -4,556 6/30/20
Simplex Trading, LLC 15,308 0.06 -- 6/30/20
California Public Employees' Retirement System 14,799 0.05 -- 6/30/20
Dowling & Yahnke, LLC 12,000 0.04 12,000 6/30/20
A.R.T. Advisors, LLC 11,800 0.03 11,800 6/30/20
William Blair & Company, L.L.C. (Research) 11,200 0.04 -- 6/30/20
RBC Capital Markets Wealth Management 7,105 0.02 -- 6/30/20
Valeo Financial Advisors LLC 2,325 0.01 -- 6/30/20
UBS Financial Services, Inc. 902 -- 902 6/30/20
Morgan Stanley Smith Barney LLC 730 -- 630 6/30/20
Northern Trust Global Investments 551 -- 201 6/30/20
Bourgeon Capital Management, LLC 317 -- -- 6/30/20
Wells Fargo Bank, N.A. 93 -- 1 6/30/20
RBC Dominion Securities, Inc. 83 -- -- 6/30/20
Steward Partners Investment Advisory, LLC 83 -- -- 6/30/20
Sonora Investment Management, LLC 16 -- -- 6/30/20
J.P. Morgan Securities LLC -- -- -65 12/31/19
PanAgora Asset Management Inc. -- -- -776 9/30/19
BNY Mellon Asset Management -- -- -27,298 3/31/19
Victory Capital Management Inc. -- -- -2,913 6/30/20
Dimensional Fund Advisors, L.P. -- -- -2,862 1/31/19

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