OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 32 13.06 50.01 10,413,449
Mutual Fund 38 0.07 0.50 102,241
Insider 10 1.86 8.13 1,693,150

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 14 2.86 11.47 2,389,392
Sellers 26 -0.51 2.04 -424,395
Net 2.35 9.44 1,964,997

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 15.66 61.62 12,832,142
Top 10 Inst. 14.66 57.64 12,003,146
Top 20 Inst. 15.29 60.69 12,637,750
Top 50 Inst. 15.66 61.62 12,832,142

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth
Aggressive Growth -- --
Core Growth 2 -- -- 453
Growth 2 -- -- 849
Income
Income Value -- --
Yield -- --
Index 5 0.22 0.84 175,737
Other 17 10.70 40.59 8,453,699
Broker Dealer 6 0.13 0.48 100,960
GARP 2 0.16 0.10 20,827
Hedge Fund 7 6.72 25.81 5,375,050
Specialty -- --
VC Private Equity 2 3.70 14.20 2,956,862
Value
Core Value 1 -- -- 504
Deep Value -- --

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 2,052,455 9.86 1 6/30/19
BVF Partners L.P. 2,035,695 9.78 -- 6/30/19
Sarissa Capital Management, L.P. 1,851,851 8.89 -- 6/30/19
Altium Capital Management LP 1,327,801 6.38 1,327,801 5/7/19
Papadopoulos (Stelios B) 1,193,201 5.73 370,370 5/22/19
EcoR1 Capital, LLC 1,111,110 5.34 -- 6/30/19
Samsara BioCapital, LLC 904,407 4.34 -206,704 6/30/19
Sanofi SA 725,543 3.48 -1 3/31/19
Heights Capital Management, Inc. 454,190 2.18 454,190 6/30/19
Renaissance Technologies LLC 346,893 1.67 71,200 6/30/19
Rastetter (William H) 157,698 0.76 92,891 5/22/19
Hagan (Joseph P) 139,016 0.67 -4,375 8/15/19
Geode Capital Management, L.L.C. 64,347 0.31 24,020 6/30/19
Aker (Christopher Ray) 53,475 0.26 -899 8/15/19
BlackRock Institutional Trust Company, N.A. 48,817 0.23 -- 6/30/19
Witz (Pascale) 41,013 0.20 29,630 5/22/19
Wedbush Securities, Inc. 33,376 0.16 -10,113 6/30/19
The Vanguard Group, Inc. 32,503 0.16 -11,070 6/30/19
Jane Street Capital, L.L.C. 32,449 0.16 -30,660 6/30/19
Chevallard (Daniel R) 31,910 0.15 -- 7/1/19
Wright (Timothy Michael) 30,223 0.15 -- 5/22/19
Collier (Kathryn J.) 20,086 0.10 -- 5/22/19
Medical Strategy GmbH 20,051 0.10 -- 6/30/18
Wells Fargo Advisors 17,177 0.08 -4,954 6/30/19
A.R.T. Advisors, LLC 16,095 0.08 5,076 6/30/19
Baltimore (David) 15,330 0.07 -- 5/22/19
Northern Trust Investments, Inc. 15,271 0.07 -- 6/30/19
California Public Employees' Retirement System 14,799 0.07 -- 6/30/19
Verition Fund Management LLC 13,206 0.06 13,206 6/30/19
Rosen (Hugh M.D., Ph.D.) 11,198 0.05 -- 5/22/19
William Blair & Company, L.L.C. (Research) 10,065 0.05 -- 6/30/19
RBC Capital Markets Wealth Management 7,828 0.04 -207 6/30/19
Independent Financial Partners 833 -- -416 3/31/19
PanAgora Asset Management Inc. 776 -- 776 6/30/19
Manulife Asset Management Limited 504 -- -- 8/31/19
Northern Trust Global Investments 350 -- -- 6/30/19
Tower Research Capital LLC 200 -- -949 6/30/19
Morgan Stanley Smith Barney LLC 103 -- -- 6/30/19
RBC Dominion Securities, Inc. 83 -- 83 6/30/19
Steward Partners Investment Advisory, LLC 83 -- 83 6/30/19
J.P. Morgan Securities LLC 65 -- 65 6/30/19
NEXT Financial Group, Inc. 50 -- -- 6/30/19
Sonora Investment Management, LLC 16 -- -- 6/30/19
UBS Financial Services, Inc. -- -- -1,969 6/30/19
Mellon Investments Corporation -- -- -2,772 6/30/18
Goldman Sachs Asset Management (US) -- -- -1,389 9/30/18
Washington Trust Bank -- -- -13 3/31/18
BNY Mellon Asset Management -- -- -27,298 3/31/19
Deutsche Asset Management Americas -- -- -8 6/30/18
Victory Capital Management Inc. -- -- -27,314 3/31/18

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