OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 33 5.31 18.77 3,857,928
Mutual Fund 50 0.39 0.98 99,105
Insider 10 2.61 9.04 1,857,416

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 24 2.88 10.82 2,222,938
Sellers 23 -1.02 4.01 -824,699
Net 1.87 6.80 1,398,239

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 16.97 31.34 6,440,888
Top 10 Inst. 15.41 28.39 5,832,943
Top 20 Inst. 16.65 30.52 6,272,336
Top 50 Inst. 16.97 31.34 6,440,888

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth
Aggressive Growth -- --
Core Growth 2 -- -- 453
Growth 2 -- -- 849
Income
Income Value -- -- -- --
Yield -- --
Index 5 0.17 0.79 162,787
Other 16 4.48 17.66 3,629,213
Broker Dealer 10 0.22 1.06 216,907
GARP 1 0.16 0.10 20,051
Hedge Fund 4 1.37 6.52 1,339,801
Specialty -- --
VC Private Equity 1 2.73 9.99 2,052,454
Value 1 -- -- 504
Core Value 1 -- -- 504
Deep Value -- -- -- --

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 2,052,454 9.99 1,136,703 5/7/19
Papadopoulos (Stelios B) 1,203,430 5.86 370,370 5/7/19
BVF Partners L.P. 1,051,940 5.12 -- 3/31/19
Sanofi SA 725,544 3.53 304,396 12/31/17
Renaissance Technologies LLC 275,693 1.34 115,625 3/31/19
Hagan (Joseph P) 262,326 1.28 182,227 5/16/19
Chevallard (Daniel R) 77,288 0.38 45,414 5/15/19
Wright (Timothy Michael) 64,560 0.31 40,000 2/5/19
Jane Street Capital, L.L.C. 63,109 0.31 63,109 3/31/19
Aker (Christopher Ray) 56,599 0.28 31,562 5/15/19
Rastetter (William H) 54,963 0.27 -- 7/31/18
BlackRock Institutional Trust Company, N.A. 48,817 0.24 -- 3/31/19
Virtu Americas LLC 48,652 0.24 48,652 3/31/19
Witz (Pascale) 47,991 0.23 29,630 5/7/19
The Vanguard Group, Inc. 43,573 0.21 -181,605 3/31/19
Wedbush Securities, Inc. 43,489 0.21 10,751 3/31/19
Baltimore (David) 43,117 0.21 40,339 11/12/18
Hauck & Aufhäuser Asset Management Services S.à r.l._NLE 42,908 0.21 42,908 9/30/17
Geode Capital Management, L.L.C. 40,327 0.20 -- 3/31/19
Collier (Kathryn J.) 25,556 0.12 23,974 11/16/18
Wells Fargo Advisors 22,131 0.11 4,551 3/31/19
Rosen (Hugh M.D., Ph.D.) 21,586 0.11 19,245 11/12/18
Medical Strategy GmbH 20,051 0.10 -- 6/30/18
Virtu Financial BD LLC 17,941 0.09 17,941 3/31/19
Susquehanna International Group, LLP 15,384 0.07 15,384 3/31/19
Northern Trust Investments, Inc. 15,271 0.07 -- 3/31/19
California Public Employees' Retirement System 14,799 0.07 -- 3/31/19
A.R.T. Advisors, LLC 11,019 0.05 11,019 3/31/19
William Blair & Company, L.L.C. (Research) 10,065 0.05 10,065 3/31/19
RBC Capital Markets Wealth Management 8,035 0.04 -416 3/31/19
Valeo Financial Advisors LLC 2,249 0.01 2,249 3/31/19
UBS Financial Services, Inc. 1,969 0.01 1,034 3/31/19
Morgan Stanley & Co. LLC 1,878 0.01 1,861 3/31/19
Group One Trading, L.P. 1,600 0.01 -- 3/31/19
Tower Research Capital LLC 1,149 0.01 -3,189 3/31/19
FIDE Capital 833 -- -- 12/31/18
Independent Financial Partners 833 -- -416 3/31/19
Bronfman E.L. Rothschild, L.P 729 -- 729 3/31/19
Manulife Asset Management Limited 504 -- 504 3/31/19
Northern Trust Global Investments 350 -- -- 3/31/19
Morgan Stanley Smith Barney LLC 103 -- -- 3/31/19
NEXT Financial Group, Inc. 50 -- -- 3/31/19
Sonora Investment Management, LLC 16 -- -- 3/31/19
Barclays Capital Inc. 7 -- -- 3/31/19
Mellon Investments Corporation -- -- -2,772 6/30/18
J.P. Morgan Securities LLC -- -- -66 12/31/18
Westfield Capital Management Company, L.P. -- -- -133 8/31/17
Goldman Sachs Asset Management (US) -- -- -1,389 9/30/18
Washington Trust Bank -- -- -13 3/31/18
PanAgora Asset Management Inc. -- -- -22,906 3/31/19

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