OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 48 57.28 49.83 37,331,111
Mutual Fund 13 17.75 16.09 11,786,020
Insider 8 5.57 4.94 3,703,865

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 29 21.67 19.26 14,429,410
Sellers 23 -23.54 20.18 -15,117,772
Net -1.87 0.92 -688,362

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 62.85 54.77 41,034,976
Top 10 Inst. 52.51 45.58 34,149,173
Top 20 Inst. 61.28 53.37 39,984,206
Top 50 Inst. 62.83 54.75 41,024,408

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth
Aggressive Growth -- --
Core Growth 4 3.55 3.03 2,273,752
Growth 1 -- -- 16
Income
Income Value -- --
Yield -- --
Index 5 5.85 5.00 3,749,383
Other 22 32.71 28.64 21,456,122
Broker Dealer 9 1.10 0.94 703,674
GARP -- --
Hedge Fund 12 21.54 19.09 14,301,392
Specialty -- --
VC Private Equity 1 10.06 8.61 6,451,056
Value 8 10.65 9.14 6,844,777
Core Value 5 9.90 8.48 6,354,099
Deep Value 3 0.76 0.65 490,678

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
New Enterprise Associates (NEA) 6,451,056 8.61 -1 3/31/21
Wellington Management Company, LLP 6,270,099 8.37 -- 3/31/21
EcoR1 Capital, LLC 3,650,080 4.87 3,650,080 12/31/20
The Vanguard Group, Inc. 3,220,758 4.30 2,834,099 3/31/21
Point72 Asset Management, L.P. 3,215,436 4.29 -- 3/31/21
Papadopoulos (Stelios B) 2,839,707 3.79 -- 3/31/21
Endurant Capital Management LP 2,376,557 3.17 2,376,557 3/31/21
Victory Capital Management Inc. 2,227,199 2.97 -6,292,043 3/31/21
Asymmetry Capital Management, L.P 1,985,472 2.65 -426,104 3/31/21
Two Sigma Investments, LP 1,912,809 2.55 1,883,093 3/31/21
Sarissa Capital Management, L.P. 1,851,851 2.47 -- 3/31/21
Ikarian Capital LLC 1,245,989 1.66 1,245,989 3/31/21
BofA Global Research (US) 489,262 0.65 489,262 3/31/21
Acadian Asset Management LLC 465,678 0.62 465,678 3/31/21
Rastetter (William H) 390,581 0.52 -- 3/31/21
Geode Capital Management, L.L.C. 381,892 0.51 317,545 3/31/21
Atom Investors LP 337,228 0.45 337,228 3/31/21
Hagan (Joseph Patrick) 312,748 0.42 -4,186 5/17/21
Focused Wealth Management, Inc. 200,000 0.27 100,000 6/30/21
Squarepoint Capital LLP 159,804 0.21 149,675 3/31/21
Morgan Stanley & Co. LLC 143,448 0.19 143,448 3/31/21
Boothbay Fund Management, LLC 141,629 0.19 141,629 3/31/21
Northern Trust Investments, Inc. 117,654 0.16 78,223 3/31/21
Grimes & Company, Inc. 60,991 0.08 6,480 3/31/21
Marshall Wace LLP 51,692 0.07 51,692 3/31/21
GYL Financial Synergies, LLC 51,376 0.07 -- 3/31/21
Witz (Pascale) 47,335 0.06 -6 3/31/21
Tower Research Capital LLC 44,806 0.06 -76,180 3/31/21
Aker (Christopher Ray) 42,754 0.06 -860 5/17/21
Collier (Kathryn J.) 27,419 0.04 -- 3/31/21
Charles Schwab Investment Management, Inc. 26,759 0.04 26,759 3/31/21
Citadel Advisors LLC 25,924 0.03 25,924 3/31/21
Baltimore (David) 25,604 0.03 -- 3/31/21
McGuire Wealth Management 24,000 0.03 -- 6/30/21
Commonwealth Financial Network 20,000 0.03 20,000 3/31/21
Morgan Stanley Smith Barney LLC 19,803 0.03 14,173 3/31/21
Goldman Sachs & Company, Inc. 18,049 0.02 -38,287 3/31/21
Rosen (Hugh M.D., Ph.D.) 17,717 0.02 -- 3/31/21
Blackstone Alternative Investment Advisors LLC 15,900 0.02 15,900 3/31/21
Jane Street Capital, L.L.C. 14,178 0.02 14,178 3/31/21
Group One Trading, L.P. 13,868 0.02 4,968 3/31/21
Axiom Asset Management 13,000 0.02 -- 6/30/21
Dowling & Yahnke, LLC 12,000 0.02 -- 6/30/21
Creative Planning, Inc. 12,000 0.02 12,000 3/31/21
William Blair & Company, L.L.C. (Research) 10,700 0.01 -500 3/31/21
Manulife Investment Management (North America) Limited 10,610 0.01 -- 6/30/21
Private Advisor Group LLC 10,000 0.01 10,000 3/31/21
Wells Fargo Advisors 7,106 0.01 -- 3/31/21
RBC Capital Markets Wealth Management 6,980 0.01 -- 3/31/21
Community Bank, N.A. 6,900 0.01 6,900 3/31/21

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