OWNERSHIP PROFILE

Shareholder Breakdown

Shareholder Holders Value ($MM) % O/S Shares
Institution 42 4.46 42.67 4,584,605
Mutual Fund 15 0.52 3.99 428,635
Insider 10 1.78 12.21 1,311,571

Institutional Shareholder Rotation

Shareholder Holders Value Chg ($MM) % O/S Share Change
Buyers 14 0.20 2.02 216,569
Sellers 38 -1.18 7.82 -840,058
Net -- -0.98 5.80 -623,489

Institutional Shareholder Concentration

Value ($MM) % O/S Shares
Total Inst. 4.46 42.67 4,584,605
Top 10 Inst. 3.97 38.77 4,165,822
Top 20 Inst. 4.34 41.55 4,464,440
Top 50 Inst. 4.46 42.67 4,584,605

Institutional Shareholder Style

Holders Value ($MM) % Inst Shares Shares
Growth 5 0.01 0.04 4,580
Core Growth 3 0.01 0.03 3,315
Growth 2 -- 0.01 1,265
Income 1 0.03 0.25 27,298
Income Value 1 0.03 0.25 27,298
Index 5 0.32 3.21 344,392
Other 16 2.11 21.12 2,268,955
Broker Dealer 7 0.06 0.57 60,848
GARP 2 0.03 0.40 42,957
Hedge Fund 6 1.16 11.63 1,249,399
VC/Private Equi 1 0.85 8.52 915,751

Top Holders: Institutional Investor

Holder Shares Held % O/S Share Change Filing Date
BVF Partners L.P. 1,051,940 9.79 -88,494 12/31/18
New Enterprise Associates (NEA) 915,751 8.52 -- 12/31/18
Papadopoulos (Stelios B) 833,060 7.75 687,311 12/28/18
Sanofi SA 725,544 6.75 304,396 12/31/17
The Vanguard Group, Inc. 225,178 2.10 7,286 12/31/18
Renaissance Technologies LLC 160,068 1.49 110,443 12/31/18
Hagan (Joseph P) 85,941 0.80 65,000 2/5/19
Wright (Timothy Michael) 64,560 0.60 40,000 2/5/19
Rastetter (William H) 54,963 0.51 -- 7/31/18
BlackRock Institutional Trust Company, N.A. 48,817 0.45 -2 12/31/18
Baltimore (David) 43,117 0.40 40,339 11/12/18
Geode Capital Management, L.L.C. 40,327 0.38 -2 12/31/18
Chevallard (Daniel R) 35,127 0.33 30,000 2/5/19
Wedbush Securities, Inc. 32,738 0.30 19,723 12/31/18
Aker (Christopher Ray) 27,747 0.26 27,747 2/5/19
BNY Mellon Asset Management 27,298 0.25 24,449 12/31/18
Collier (Kathryn J.) 25,556 0.24 23,974 11/16/18
PanAgora Asset Management Inc. 22,906 0.21 12,316 12/31/18
Two Sigma Investments, LP 22,216 0.21 20,761 12/31/18
Rosen (Hugh M.D., Ph.D.) 21,586 0.20 19,245 11/12/18
Medical Strategy GmbH 20,051 0.19 -39,283 6/30/18
Witz (Pascale) 18,361 0.17 15,833 11/12/18
Wells Fargo Advisors 17,580 0.16 -5,936 12/31/18
Northern Trust Investments, Inc. 15,271 0.14 407 12/31/18
California Public Employees' Retirement System 14,799 0.14 -1 12/31/18
Citadel LLC 10,671 0.10 10,671 12/31/18
RBC Capital Markets Wealth Management 8,451 0.08 -2,599 12/31/18
Tower Research Capital LLC 4,338 0.04 4,338 12/31/18
Dimensional Fund Advisors, L.P. 2,862 0.03 2,862 10/31/18
We Are One Seven, LLC 2,000 0.02 -- 12/31/18
Group One Trading, L.P. 1,600 0.01 1,600 12/31/18
Independent Financial Partners 1,249 0.01 1,249 12/31/18
UBS Financial Services, Inc. 935 0.01 -405 12/31/18
FIDE Capital 833 0.01 -- 9/30/18
Bank of America Merrill Lynch (US) 455 -- 455 12/31/18
Northern Trust Global Investments 350 -- -2 12/31/18
Ladenburg Thalmann Asset Management Inc. (LTAM) 166 -- -1 12/31/18
Morgan Stanley Wealth Management 103 -- -42 12/31/18
NEXT Financial Group, Inc. 50 -- -- 12/31/18
Morgan Stanley & Co. LLC 17 -- 9 12/31/18
Sonora Investment Management, LLC 16 -- -1 12/31/18
Barclays Capital Inc. 7 -- -659 12/31/18

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