Press Releases.

Regulus Announces Commencement of Public Offering of Common Stock

LA JOLLA, Calif., July 19, 2017 /PRNewswire/ -- Regulus Therapeutics Inc. (NASDAQ: RGLS), a biopharmaceutical company developing innovative medicines targeting microRNAs, today announced that it has commenced an underwritten public offering, subject to market and other conditions, to issue and sell shares of its common stock.  In connection with the offering, Regulus expects to grant the underwriters a 30-day option to purchase up to an additional 15% of the shares of common stock offered in the public offering.  Regulus intends to use the net proceeds from the offering to fund clinical development of its clinical candidates, RG-012 and RGLS4326, development of its earlier microRNA development candidates and programs, for the identification and validation of additional microRNA targets, and for capital expenditures, working capital and general corporate purposes.  There can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

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Leerink Partners is acting as sole book-running manager in the offering.

The securities described above are being offered by Regulus pursuant to a shelf registration statement on Form S-3, including a base prospectus, that was previously filed by Regulus with the Securities and Exchange Commission (the "SEC") and that was declared effective on May 2, 2016.  A preliminary prospectus supplement and accompanying prospectus relating to the offering will be filed with the SEC and will be available for free on the SEC's website located at  Copies of the preliminary prospectus supplement and the accompanying prospectus relating to the offering, when available, may be obtained from Leerink Partners LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA02110, or by telephone at (800) 808-7525, ext. 6132, or by email at  

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

About Regulus

Regulus is a biopharmaceutical company developing innovative medicines targeting microRNAs.  Regulus is advancing several programs in renal, hepatic and central nervous systems diseases.  Regulus maintains its corporate headquarters in La Jolla, CA.

Forward-Looking Statements

Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995.  Such forward-looking statements include, without limitation, statements about Regulus' proposed offering of common stock, its expectations with respect to granting the underwriters a 30-day option to purchase additional shares, its intended use of proceeds from the offering and the expected ability of Regulus to undertake certain activities and accomplish certain goals with respect to its development programs. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Words such as "believes," "anticipates," "plans," "expects," "intends," "will," "goal," "potential" and similar expressions are intended to identify forward-looking statements. These forward-looking statements are based upon Regulus' current expectations and involve assumptions that may never materialize or may prove to be incorrect.  Actual results and the timing of events could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks associated with market conditions and the satisfaction of closing conditions related to the proposed public offering, as well as risks and uncertainties associated with Regulus' business and finances in general, and the other risks described in Regulus' quarterly report on Form 10-Q for the quarter ended March 31, 2017 and other filings with the SEC.  All forward-looking statements contained in this press release speak only as of the date on which they were made. Regulus undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.


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SOURCE Regulus Therapeutics Inc.

For further information: Investor Relations, Allison Wey, Vice President, Investor Relations and Corporate Communications, Regulus Therapeutics Inc., 858-202-6321,