PRESS RELEASES

Date Title and Summary View
Toggle Summary Regulus Therapeutics Inc. presents: “MicroRNA: The Year in Review and a Look Ahead”
Webinar to Discuss Recent microRNA Discoveries and Potential Applications in Medicine Scheduled for 3:00 p.m. EST on December 14, 2009 A discussion with leading microRNA scientists Tom Tuschl, Ph.D. Professor at Rockefeller University and Markus Stoffel, MD, Ph.D. Professor at the Swiss Federal Institute of Technology
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Toggle Summary Regulus Announces U.S. Allowance of Fundamental microRNA Therapeutics Patent Application
Esau patent family broadly covers microRNA therapeutics, including mir-122
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Toggle Summary Regulus, Alnylam, and Isis Announce First microRNA Patent Grant in Japan from Tuschl III Patent Series
Tuschl III Patent Exclusively Licensed from Max Planck
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Toggle Summary Regulus Therapeutics Appoints Hubert C. Chen, M.D., Vice President of Translational Medicine
Regulus Therapeutics Appoints Hubert C. Chen, M.D., Vice President of Translational Medicine CARLSBAD, Calif., September 17, 2009 – Regulus Therapeutics Inc., a leading microRNA therapeutics company, today announced the appointment of Hubert C. Chen, M.D., as Vice President of Translational
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Toggle Summary Alnylam and Regulus Receive Notice of Allowance from United States Patent and Trademark Office for New Patent Covering microRNA Therapeutics
Manoharan Patent Covers Antagomirs, a Chemical Class of microRNA Inhibitors
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Toggle Summary Isis and Alnylam Launch Regulus Therapeutics, a Joint Venture to Discover, Develop, and Commercialize microRNA Therapeutics
By Targeting Gene Pathways, microRNA Therapeutics Represent a New Approach for the Treatment of a Broad Range of Human Disease
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Toggle Summary Releases Regulus Therapeutics Achieves Initial Milestone in its Inflammatory Diseases Collaboration with GlaxoSmithKline
First demonstration of a target-specific pharmacological effect for a microRNA antagonist in immune cells
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Toggle Summary Regulus Therapeutics Receives $20 Million in a Series A Equity Financing
The leading microRNA therapeutics company further strengthens balance sheet to advance programs towards the clinic
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Toggle Summary Regulus Therapeutics, Alnylam Pharmaceuticals, and Collaborators Publish First Ever In Vivo Efficacy Data for a microRNA Therapeutic in a Disease Model
New findings published in the journal Nature demonstrate therapeutic benefit of anti-microRNA-21 in an animal model of heart failure  **Companies to host conference call Monday, December 1, 2008 at 8:30 a.m. ET to discuss results
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Toggle Summary Regulus Therapeutics and Collaborators Discover Role of a microRNA in Tumor Angiogenesis
New Findings Published in the Journal Cancer Cell Highlight Role of miR-296 in Regulating Pathways of Angiogenesis and Demonstrate Potential New Applications of microRNA Therapeutics in Cancer
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